Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018

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Sanjay Gandhi institute of trauma and orthopedics,
On Aug 2018

Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".

Dr. Mamta Gupta
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018

Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.

Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."

Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2023 | Month : September | Volume : 17 | Issue : 9 | Page : YC01 - YC04 Full Version

Correlation of Toe Grip Strength among Individuals with Knee Osteoarthritis with and without Fear of Pain: A Cross-sectional Study

Published: September 1, 2023 | DOI:
Shreya Vinodara Poojari, Saumya Srivastava

1. Postgraduate Student, Department of Physiotherapy, Nitte Institute of Physiotherapy, NITTE (Deemed to be University), Mangalore, Karnataka, India. 2. Associate Professor, Department of Physiotherapy, Nitte Institute of Physiotherapy, NITTE (Deemed to be University), Mangalore, Karnataka, India.

Correspondence Address :
Dr. Saumya Srivastava,
Nithyananda Nagar, Deralakatte, Mangalore-575018, Karnataka, India.


Introduction: Knee Osteoarthritis (OA) is a common degenerative joint disease that affects millions of people worldwide. It is characterised by progressive loss of joint cartilage, resulting in pain, stiffness, and significant disability, leading to a reduced quality of life. Fear of pain is a significant psychosocial factor that affects individuals with knee OA, leading to decreased physical activity. However, the relationship between Toe Grip Strength (TGS) and fear of pain in individuals with knee OA is poorly understood, even though fear of pain has been known to impact strength in both the upper and lower limbs.

Aim: To examine the correlation between fear and TGS among individuals with knee OA, both with and without fear of pain.

Materials and Methods: This cross-sectional study was conducted at the Department of Physiotherapy, Nitte Institute of Physiotherapy, affiliated with the University of Mangalore, Karnataka, India, from April 2022 to March 2023. The study included 60 individuals, with 30 in each group, diagnosed with knee OA using the Kellgren and Lawrence (KL) grading system (grade 2 and above). The participants, both men and women aged between 45 and 80 years, were informed about the study’s purpose. The Fear Avoidance Belief Questionnaire (FABQ) form was completed by the screened patients, who were then divided into fear and non fear groups. Body Mass Index (BMI) was determined by measuring height with a wall-mounted device and weight using a traditional analog scale. TGS was evaluated in both groups using a pinch grip dynamometer. The Pearson correlation coefficient was used for data analysis, with a p-value <0.05 considered statistically significant.

Results: The results of the current study indicated that the FABQ showed a negative correlation (p-value >0.05) with TGS (both right and left-side) (r: -0.296 (right) and -0.302 (left)), and a positive correlation (p-value<0.05) with the Numerical Pain Rating Scale (NPRS) (both during activity and at rest).

Conclusion: This study revealed a significant association between fear and TGS in individuals with knee OA. Notably, Fear Avoidance Beliefs (FAB) exhibited a negative correlation with TGS while demonstrating a positive correlation with pain levels.


Fear, Gait, Lower limb, Pinch gauge dynamometer, Upper limb

Worldwide, OA affects an estimated 10% of the male population and 18% of the female population over 60 years of age, making it one of the most common diseases to affect the elderly population (1). The knee joint complex is the most commonly affected joint in OA, often accompanied by painful clinical symptoms and disability (2). The natural prognosis of knee OA varies, as the disease can improve, remain stable, or gradually worsen in different patients (3). Numerous researchers have extensively studied the relationship between altered knee joint mechanics and foot posture in OA [4,5]. Abnormal knee and foot loading can result in altered foot and knee kinematics (4). Findings from studies conducted by Douglas Gross K et al., indicated that foot structure characteristics were associated with knee pathology, while Uritani D et al., theorised a link between TGS, altered forefoot function, and the occurrence or progression of knee OA (6),(7). Patients with knee OA may reduce their knee extensor moment while walking to minimise pain (8). Toe flexor function is crucial during gait, particularly during the terminal stance phase, where it contributes to the windlass mechanism. This mechanism relies on rigid supination of the foot during the push-off phase, which facilitates smooth body progression during walking. However, in clinical practice, it is common to observe difficulties in patients with knee OA maintaining toe contact with the ground during the stance phase of gait until push-off, suggesting a possible association between knee OA and toe flexor dysfunction during walking. Therefore, it is important to investigate how flexor hallucis longus strength varies in individuals with knee OA (7).

Research has demonstrated that individuals with knee OA have weaker TGS compared to healthy individuals (7). This weakness can lead to compensatory movements that contribute to pain and fear of movement in the affected joint. Pain, a common symptom of knee OA, can instill fear of movement or avoidance of activities that exacerbate pain. This fear can result in physical inactivity and muscle weakness, further contributing to pain and disability (8). The Fear-Avoidance Model (FAM) is a well-suited model that establishes the relationship between the psychological aspect of pain and its impact on physical function (9). There is a connection between how people cope with stress, their belief in their own problem-solving abilities, and the negative impact these factors can have on their mental health, pain levels, and ability to function normally. When individuals experience negative effects, they tend to avoid activities that cause pain, leading to weaker muscles, and more pain and disability (10). The Fear-Avoidance Model (FAM) describes the development of chronic pain and has been extensively studied in relation to OA.

A definitive association between TGS and fear of movement has not been established. Therefore, this study aims to provide valuable insights into the relationship between fear of movement and TGS, enabling physiotherapists to develop targeted interventions to improve outcomes in patients with knee OA. The primary objective of this study was to assess TGS among individuals with knee OA, both with and without fear of movement, to gain insights into their functional capacity, compensatory mechanisms, fall risk, and treatment needs. The secondary objective was to determine whether fear influences pain levels among these individuals. This assessment can guide healthcare professionals in designing appropriate interventions to enhance mobility, reduce pain, and improve overall quality of life.

Material and Methods

A cross-sectional study was conducted at the Department of Physiotherapy, Nitte Institute of Physiotherapy, affiliated with the University in Mangalore, Karnataka, India, from April 2022 to March 2023. Approval was obtained from the Institutional Ethics Committee (IEC) (NIPT/IEC/MIN/16/2021-2022).

Inclusion criteria: The study included individuals diagnosed with knee OA using the KL grading system (grade 2 and above) (11), including both men and women aged between 45 and 80 years. Both unilateral and bilateral knee OA were considered.

Exclusion criteria: Individuals with lower limb injuries, fractures, neurological symptoms, current ankle injuries, or current toe injuries were excluded from the study.

Sample size: The sample size was calculated based on the Standard Deviation (SD) of TGS in kilograms (3.3 SD in Group 1, SD in group 4.8%) (7). The mean difference was set at 3, effect size at 0.5231, α error at 5%, and power at 80% for the two-sided hypothesis test. A total of 30 participants per group were required, resulting in a total sample size of 60. This calculation was performed using nMaster software version 2.


The patients underwent screening based on the inclusion and exclusion criteria. The purpose of the study was explained, and written consent forms were obtained from the screened subjects. Demographic data of the patients were collected and recorded. The screened patients filled out the FABQ (12) and were divided into two groups: one group with fear and another without fear. TGS was assessed using a pinch grip dynamometer (Lafayette Pinch Gauge®-J00111) in both groups. For BMI, height was measured using a wall-mounted height measuring device, and weight was assessed using a traditional analog scale.

The patients were instructed to sit comfortably on a stool while the pinch gauge dynamometer was placed under their great toe, with the pressure pad directly below the distal crease of the metatarsophalangeal joint. They were then instructed to press their great toe as hard as they could without lifting their heel for three seconds, while the tester secured the foot with one hand and ensured that it remained in a neutral position. Patients were advised not to lean forward during the procedure (Table/Fig 1). The therapist measured and recorded the forces exerted by the toe on the pressure pad for each trial before returning the Peak-Hold Needle to 0. This process was repeated three times in a row (13).

Outcome Measures

Fear Avoidance Questionnaire (FABQ) (12): The FABQ assesses beliefs and pain-related fears regarding the need to change behaviours to avoid pain. It consists of 16 items, each scored on a scale of 0 to 6, with higher numbers indicating higher levels of fear-2avoidance beliefs. The FABQ is divided into two subscales: work (FABQ-W) and physical activity (FABQ-PA). The tool has excellent reliability with an ICC of 0.88.

Pinch gauge dynamometer: The pinch dynamometer is a valid and reliable instrument for measuring pinch grip strength and small muscle group strength, as demonstrated in a study by Shamus J et al., (14).

Numerical Pain Rating Scale (NPRS): An 11-point NPRS ranging from 0-10, with 0 indicating “no pain” and 10 indicating “worst imaginable pain.” Higher scores indicate greater pain intensity (15).

Statistical Analysis

The data were analysed using Statistical Package for the Social Sciences (SPSS) software (version 26.0, SPSS Inc.; Chicago, IL). Descriptive statistics (frequency, percentage, mean, and SD) were used to summarise the collected data. The unpaired t-test was used to compare age, BMI, FABQ, TGS, and NPRS between the groups. The Chi-square or likelihood ratio test was used to compare gender, KL grading, and affected leg between the groups. The paired t-test was used to compare TGS and NPRS. The Pearson correlation coefficient was used to find the relationship between age, BMI, FABQ, TGS, and NPRS. A p-value <0.05 was considered statistically significant.


This study was conducted among 60 individuals with knee OA. The participants were divided into two groups: the ‘with fear’ group and the ‘without fear’ group, each consisting of 30 participants. The majority of the participants (66.7%) were females. The age of the participants ranged from 45 to 80 years, with a mean of 59.8±8.4 (Table/Fig 2).

Th FABQ, TGS (right and left), NPRS range mean ±SD is given in (Table/Fig 3). (Table/Fig 4) describes the various characteristics of the study participants in the two groups. In group 1 and group 2, the mean BMI, KL grading and FABQ scores are shown respectively.

(Table/Fig 5) depicts the TGS in the two groups. It can be observed that on the right side, TGS in group 1 and group 2 was 2.0±0.6 and 2.6±1.3, respectively. Hence, it can be inferred that TGS on the right side was lower among patients with fear compared to the patients without fear. Using an unpaired t-test, a statistically significant difference was observed in the TGS (right-side) between the groups (p-value<0.05).

On the left side, the toe grip strength in group 1 and group 2 was observed to be 2.0±0.6 and 2.633±1.4, respectively. It can be inferred that the TGS on the left side was comparatively lower among patients with fear compared to the patients without fear. Using an unpaired t-test, a statistically significant difference is observed in TGS (left-side) between the groups (p-value<0.05).

The Chi-square or Likelihood ratio test was used to compare gender, KL grading, and affected leg between the groups. There was a difference (p-value<0.05) in KL Grading as well as the affected leg between the groups (Table/Fig 6). The NPRS scores of the study participants in the two groups are depicted in (Table/Fig 7).

It can be inferred from the table that the NPRS for both activity and rest was higher among patients with fear compared to patients without fear. An unpaired t-test revealed a statistically significant difference between the groups in the mean NPRS for activity (p-value<0.001) and for rest (p-value<0.01).

A paired t-test was used to compare TGS and NPRS. There was a statistically significant difference (p-value<0.05) in NPRS between activity and rest (Table/Fig 8).

The paired t-test was used to compare TGS and NPRS within the groups. There was a difference (p-value<0.05) in NPRS between activity and rest within both the groups: with fear and without fear (Table/Fig 9).

The Pearson correlation coefficient was used to determine the relationship between FABQ, TGS, and NPRS. FABQ showed a negative correlation (p-value>0.05) with TGS (both right and left-side) and a positive correlation (p-value<0.05) with NPRS (both for activity and rest). TGS on the right side showed a positive correlation (p-value<0.05) with the left side and a negative correlation (p-value<0.05) with NPRS (both for activity and rest). Additionally, TGS on the left side showed a negative correlation (p-value<0.05) with NPRS (both for activity and rest) (Table/Fig 10).

The Pearson correlation coefficient was used to determine the relationship between age, BMI, FABQ, TGS, and NPRS. There was no correlation (p-value>0.05) observed between age, BMI, FABQ, toe grip strength, and NPRS (Table/Fig 11).


Knee OA is a common degenerative joint disease that affects millions of people worldwide. It is characterised by progressive loss of joint cartilage, pain, and stiffness, leading to significant disability and decreased quality of life. Fear of pain is a significant psychosocial factor affecting people with knee OA, resulting in decreased physical activity and poor functional outcomes (7). However, the role of TGS in people with knee OA and its relationship with fear is not well understood.

A study conducted by Gunn AH et al. found an association between fear of movement and knee OA patients, concluding that there is a clear association between the two variables (16). The present study also showed similar results, with a notable decrease in TGS among those with a fear of movement. When we experience fear, our bodies respond by releasing stress hormones such as cortisol, which can cause the muscles to tense up and eventually result in decreased strength (17). Therefore, the purpose of the present study was to explore the relationship between fear and strength among individuals with knee OA.

Yardimci B et al., found that upper extremity strength was reduced in those with a fear of falling (18). Another study found similar results, with lower extremity strength being reduced in individuals with fear (19). The present study also demonstrated a negative correlation between fear and toe grip strength when measured using FABQ, respectively, in individuals with knee OA, which means that the higher the belief in fear, the lower the strength (p-value>0.05). The secondary goal of the study also revealed a positive relationship between fear and NPRS, implying that the more fear, the more pain (p-value<0.05). Furthermore, the study discovered that TGS was negatively correlated with pain score, implying that people with higher TGS may have less pain. Similarly, Markfelder T and Pauli P conducted a study that found a positive relationship between fear of pain and pain intensity (20). These findings suggest that improving TGS through exercise or other interventions may be a viable treatment option for individuals with knee OA. Ingaki Y et al., conducted a study that showed that increasing age and TGS are related to falls in older adults with knee OA, highlighting the significance of evaluating TGS among patients with knee OA in routine clinical practice (21).

Overall, the study findings suggest that fear of pain negatively impacts TGS in individuals with knee OA. Therefore, TGS and fear are both important factors to consider when it comes to physical activity, stability, and quality of life in knee OA patients. The study’s findings highlight the importance of addressing psychosocial factors such as fear of pain in the management of knee OA. By improving TGS and learning how to manage your fear response, one can improve their overall physical abilities and reduce the risk of falls and injuries. Treatment can involve a variety of approaches, including education about the safety and benefits of exercise and setting realistic goals (21).


The present study had limitations such as the two groups not being homogeneous with respect to age and gender. Additionally, being a cross-sectional study, causation could not be established.


The study concluded that there was a significant relationship between fear and TGS among individuals with knee OA, both with and without fear of pain. FAB and TGS were negatively correlated, and FABQ was positively correlated with pain. The study provides insights into the importance of assessing TGS in individuals with knee OA and the correlation of fear of pain with TGS.


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DOI and Others

DOI: 10.7860/JCDR/2023/65230.18377

Date of Submission: May 08, 2023
Date of Peer Review: Jun 27, 2023
Date of Acceptance: Aug 10, 2023
Date of Publishing: Sep 01, 2023

• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes

• Plagiarism X-checker: May 09, 2023
• Manual Googling: Jul 12, 2023
• iThenticate Software: Aug 08, 2023 (12%)

ETYMOLOGY: Author Origin


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