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Dr Mohan Z Mani

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Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
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I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




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" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Reviews
Year : 2023 | Month : June | Volume : 17 | Issue : 6 | Page : SE01 - SE03 Full Version

Tomato Flu- A New Virus Trending in Children


Published: June 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/61125.18069
Pritama Paul, Sritama Paul, Nikhil Era, Kanai Lal Barik, Uttam Kumar Paul

1. Trainee (Postgraduate), Department of Pharmacology, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India. 2. Student, Department of Biotechnology, Amity University, Kolkata, West Bengal, India. 3. Associate Professor, Department of Pharmacology, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India. 4. Professor, Department of Paediatrics, Burdwan Medical College, West Bengal, India. 5. Professor, Department of Medicine, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India.

Correspondence Address :
Uttam Kumar Paul,
Professor, Department of Medicine, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India.
E-mail: druttam131065@gmail.com

Abstract

The new tomato flu virus has caused a new wave of concern, particularly in young people, as people try to live with Coronavirus Disease-2019 (COVID-19) infections and the undetected existence of monkeypox infections. The flu virus derives its name from the red blisters that resemble tomatoes and spread throughout the body of an affected person. Children between the ages of one and five and elderly people with compromised immune systems are frequently affected. Mouth ulcers, blisters, rashes, coughing, fever, sneezing, or runny nose, skin irritation, discolouration of the hands and legs, exhaustion, abdominal pains, nausea, vomiting, or diarrhoea, bodyaches, and joint pain are the main warning signs and symptoms of tomato flu. To treat tomato flu, supportive measures and fever-reducing drugs like acetaminophen or ibuprofen may also be administered. Antiviral medicines and immunisations are currently still unable to cure or prevent tomato flu. In order to properly address the epidemic, research should be focused in the future on the readiness of effective treatments and immunisations.

Keywords

Antiviral medicine, Blisters, Epidemic, Fever, Immunisations, Rash

Everyone has been residing in enclosed indoor quarters safe from illnesses since March 2020 (1). People are becoming more aware of emerging endemics as a result of the relaxation of limitations and return to normalcy in life. Children’s exposure to the outside world and illnesses has risen as a result of the reopening of schools. As tomato flu is highly contagious, so the cases are rising. While people are attempting to live with COVID-19 infections and the undetectable presence of monkeypox infections, the new tomato flu virus has sparked a fresh wave of anxiety, particularly in young people [2,3].

Since viral infections are widespread in children this age and propagation is most probable through close contact, children are more likely to be exposed to tomato flu. Young children can be infected by this virus by touching dirty surfaces, using diapers, and putting objects directly in their mouths (4). Given its resemblance to Hand-Foot-and-Mouth Disease (HFMD), tomato flu transmission can have serious consequences by spreading to adults if outbreaks in children are not controlled and prevented.

A newborn may get the virus from a mother who contracts it just before giving birth (5). A newborn’s risk of infection increases if the mother was suffering from enterovirus illness at the time of delivery. Most neonates infected with enteroviruses only experience a mild illness, but in rare instances, the infection may become serious and involve vital organs like the heart or liver and result in death [6,7]. The purposes of the review are to increase awareness of the disease among first-contact healthcare providers, thus enable early detection and facilitate rapid and efficient treatment.

Indian Scenario of Tomato Flu

The first tomato flu case was recorded on May 6, 2022, in the Kollam district of Kerala; by July 26, 2022, the local government hospitals had identified the illness in more than 82 children under the age of five. The other areas of Kerala that are affected are Anchal, Aryankavu, and Neduvathur (8),(9). The neighbouring states of Tamil Nadu and Karnataka were alerted to this endemic viral disease. The Regional Medical Research Centre in Bhubaneswar also revealed that 26 youngsters (aged 1-9 years) in the state of Odisha had the illness. Other than Kerala, Tamil Nadu, and Odisha, no other parts of India have experienced the virus’s effects as of yet. To monitor the viral infections spread and stop it from spreading to other regions of India, the Kerala Health Department is taking precautions (4),(8),(9). Tomato flu-affected states are shown in (orange coloured) (Table/Fig 1).

According to a report in UK, two children were suspected to be infected with tomato flu virus after their return from a trip to Kerala, India. But later on, it was diagnosed differently (10). Previously, Coxsackie Virus A16 (CV-A16) (tomato flu was reported to cause fatal cases of HFMD in mainland China, France, Japan, Taiwan, and the United States. In 2010, 92 cases of HFMD with neurological dysfunction were reported in Shenyang, China. Nineteen cases were reported to be due to CV-A16 infection, of which two had brainstem encephalitis and one had acute flaccid paralysis (11).

Similarities Between Other Illnesses and Tomato Flu

The basic symptoms of tomato flu in children are thought to be identical to those of chikungunya or dengue, and the blisters may resemble chickenpox or even monkeypox [12,13]. To rule out viral illnesses like dengue or chikungunya, a thorough clinical examination and laboratory tests should be performed. Chickenpox can be distinguished from tomato flu by the fact that it does not result in blisters beneath the palm and feet (14).

The primary distinction between monkeypox and tomato flu, a kind of HFMD, is that monkeypox is uncommon in children while HFMD primarily affects those under the age of seven. HFMD rashes mainly affect the palms, soles, and mouth. Although the buttocks and thighs might also develop these rashes, having rashes all over the body is unusual. They often aren’t serious and go away on their own (15). Monkeypox, on the other hand, causes consecutively spreading rashes from head to toe. It is typical for the face, genital region, palms, and soles to be affected. The rashes appear one to three days after the onset of the fever and can persist for two to four weeks (16),(17).

TOMATO FLU

Signs and Symptoms

Mouth ulcers, blisters, and rashes can occur in tomato flu [Table/Fig-2,3]. The blisters initially appear as tiny red blisters that resemble tomatoes as they grow in size [9,18]. The primary signs and symptoms of tomato flu in children include fever, rashes, and joint discomfort, which are also characteristics of other viral illnesses. Along with weariness, nausea, vomiting, diarrhoea, a fever, dehydration, joint swelling, bodyaches, and other influenza-like symptoms are all among the symptoms [18,19]. Mild fever, low appetite, lethargy, and frequently a sore throat are the first symptoms. Small red spots start to appear one or two days after the fever starts and they quickly develop into blisters and then ulcers. The tongue, gums, and inside of the cheeks, palms, and soles are the typical sites for the sores. It usually resolves within 7-10 days (4).

- Coughing, fever, sneezing, or runny nose: These signs of coronavirus infection are also rather typical in cases of tomato flu.

- Skin irritability: This is one of the most typical signs of tomato flu.

- Discolouration: Legs and hands are discoloured and become marginally unrecognisable.

- Tiredness and fatigue: They can also pose a health concern.

- Bodyaches and joint pain: A Tomato virus afflicted child can have trouble due to bodyaches and joint pain (19).

The characterstic rashes are shown in [Table Fig-3],[Table Fig-4] (20),(21).

Diagnosis

When dengue, chikungunya, varicella-zoster, zika, and herpes are ruled out as viral infections in children who exhibit these symptoms, 2molecular and serological testing is performed to confirm tomato flu virus infection [14,22-25].
Treatment (26)
Supportive management: Intake of more fluids to maintain hydration, rest, and hot water sponge baths to relieve irritation from rashes is given.
Specific management: Specific management is not available but children may be given antipyretic and analgesic medications such as ibuprofen or acetaminophen and other symptomatic treatments are required.
R
ole of antimicrobials and vaccines: Tomato flu cannot be treated or prevented with antiviral medications or vaccinations. To better understand the need for prospective treatments, additional follow-up and monitoring for significant outcomes and sequelae are required.

Preventive Measures

Here are some precautions against the tomato flu (4),(26):

• Body should be kept properly hydrated by drinking extra boiled water, juices, and other liquids.
• Patients should avoid transmission by circumventing touching blisters; maintaining good personal hygiene; and keeping a physical distance from suspicious instances. Adequate rest is needed to prevent the tomato flu’s long-lasting symptoms.
• The tomato flu is remarkably contagious, just like other influenza types. Therefore, it is crucial to properly isolate any confirmed or suspected cases of the tomato flu virus and implement additional preventative measures in order to stop the virus’s spread. Isolation should be used for 5-7 days after the onset of symptoms to prevent the virus from transmitting to other children or adults.
• The best way to prevent infection is to maintain proper hygiene, sanitise the surroundings, and restrict a sick child from sharing toys, clothes, food, or other items with other children who are not ill.

Conclusion

There is a rise in the flu and other viral infections as a result of the weather change. The highly contagious tomato flu virus is transmitted to young infants by contact with contaminated surfaces, diaper use, or direct oral contact. The tomato flu can result in blisters, rashes, mouth ulcers, etc. Laboratory testing is done to see if a child has a tomato virus infection. In the course of treatment, supportive measures as well as medications such as acetaminophen or ibuprofen are used to lower the temperature. The greatest methods for preventing infection are practicing good hygiene, sterilising the surroundings, and preventing a sick child from sharing toys, clothes, food, or other items with other kids who are healthy. Tomato flu is still not curable or preventable with antiviral drugs or vaccinations. Future research should concentrate on the readiness of efficient therapies and vaccinations in order to appropriately handle the epidemic.

References

1.
Jeffrey G, Kai S. Modi Orders 3-Week Total Lockdown for All 1.3 Billion Indians. The New York Times. (24 March 2020). ISSN 0362-4331 (Available at: https://dx.doi.org/10.18203/2394-6040.ijcmph20205191. Accessed on Dec 29, 2022.). [crossref]
2.
Benvenuto D, Giovanetti M, Ciccozzi A, Spoto S, Angeletti S, Ciccozzi M. The 2019-new coronavirus epidemic: Evidence for virus evolution. J Med Virol. 2020;92(4):455-59. [crossref][PubMed]
3.
Chavda VP, Apostolopoulos V. Is booster dose strategy sufficient for omicron variant of SARS-CoV-2? Vaccines. 2022;10(3):367-69. [crossref][PubMed]
4.
Aswini S, Anil A, Dutta G, Sharma RP, Dutta S, Kumar T, et al. Tomato Flu-a review on existing scenario. Int J Pharm Sci Rev Res. 2022;75(2):196-99. [crossref]
5.
CDC. Pregnancy & Non-Polio Enterovirus Infection, August 8, 2020. [Available at: https://www.cdc.gov/non-polioenterovirus/pregnancy.html. Accessed Dec 22, 2022].
6.
Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52(6):851-57. [crossref][PubMed]
7.
Abzug MJ. Presentation, diagnosis, and management of enterovirus infections in neonates. Paediatr Drugs. 2004;6(1):01-10. [crossref][PubMed]
8.
Sudhakar K. Alert in Karnataka over tomato flu. The Hindu. May 12, 2022. https://www.thehindu.com/news/national/karnataka/alert-in-karnataka-over-tomato-flu/article65405330.ece Date accessed: October24, 2022.
9.
Jacob J. How Kerala is battling “tomato flu” outbreak. India Today, May 15, 2022. [Available at: https://www.indiatoday.in/india-today-insight/story/how-Kerala-is-battling-tomato-flu-outbreak-1949473-05-15. Date accessed: October 19, 2022].
10.
Thiagarajan K. Reports of “tomato flu” outbreak in India are not due to new virus, say doctors. BMJ [Internet]. 2022;378:o2101. Available from: https://www.bmj. com/content/378/bmj.o2101. [crossref][PubMed]
11.
Ismail A, Saahath A, Ismail Y, Ismail MF, Zubair Z, Subbaram K. Tomato flu’ a new epidemic in India: Virology, epidemiology, and clinical features. New Microbes New Infect. 2022;51:101070. Doi: 10.1016/j.nmni.2022.101070. [crossref][PubMed]
12.
Schwartz O Albert M. Biology and pathogenesis of Chikungunya virus. Nat Rev Microbiol. 2010;8:491-500. https://www.nature.com/articles/nrmicro2368. [crossref][PubMed]
13.
Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016;2:16055. Doi: 10.1038/nrdp.2016.55. [crossref][PubMed]
14.
Espy MJ, Teo R, Ross TK, Svien KA, Wold AD, Uhl JR, et al. Diagnosis of varicella-zoster virus infections in the clinical laboratory by light cycler PCR. J Clin Microbiol. 2000;38(9):3187-89. [crossref][PubMed]
15.
S ´ lebioda Z, Dorocka-Bobkowska B. Hand, foot and mouth disease as an emerging public health problem: Case report of familial child-to-adult transmission. Dent Med Probl. 2018;55(1):99-104. [crossref][PubMed]
16.
Paul P, Singh R, Era N, Paul S, Paul UK. Monkeypox: Current trends and therapeutic challenges. Ann Med Sci Res. 2022;1:104-10. https://journals. lww.com/amsr/_layouts/15/oaks.journals/downloadpdf.aspx?an=02273472- 202209000-00002. [crossref]
17.
Chavda VP, Apostolopoulos V. Rare monkey pox: Is it really a threat to the elderly? Maturitas. 2022;163:90-91. Doi: 10.1016/j.maturitas.2022.05.014. Epub 2022 Jun 9. [crossref][PubMed]
18.
Goshwami S. Tomato fever symptoms, cause, treatment, precautions [Internet]. DMER Haryana [cited 2022 Dec 23]. Available from: https://dmerharyana.org/ tomato-fever.
19.
Barigala DRA. Tomato flu-all you need to know [Internet]. Apollo Hospitals Blog. 2022. [Available from: https://healthlibrary.askapollo.com/tomato-flu-all-you-need-to-know. Accessed on 22 Dec 2022].
20.
Tomato flu: 26 cases detected in Odisha, all you need to know about the virus [Internet]. DNA India. [Available from: https://www.dnaindia.com/ health/report-tomato-flu-26-cases-detected-in-odisha-all-you-need-to-know-about-virus-symptoms-hand-foot-and-mouth-disease-2955475. Accessed on 21st October 2022].
21.
Arfa Javaid, Jagranjosh, May 18, 2022, “What is tomato fever? Check symptoms, causes, treatment and precautions.” [Available at: https://www.jagranjosh.com/ general-knowledge/what-is-tomato-fever-check-symptoms-causes-treatment-and-precautions-1652872776-1. Accessed on 21st October 2022].
22.
Hasan S, Jamdar SF, Alalowi M, Al Ageel Al Beaiji SM. Dengue virus: A global human threat: Review of literature. J Int Soc Prev Community Dent. 2016;6(1):01-06. [crossref][PubMed]
23.
Cunha RVD, Trinta KS. Chikungunya virus: Clinical aspects and treatment-a review. Mem Inst Oswaldo Cruz. 2017;112(8):523-31. [crossref][PubMed]
24.
Simpson DIH. Zika virus infection in man. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1964;58(4):335-38. [crossref][PubMed]
25.
Mindel A. Cutaneous herpes simplex infection. Scand J Infect Dis Suppl. 1991;80:47-52. https://pubmed.ncbi.nlm.nih.gov/1803499/.
26.
Paul P, Nath R, Gupta S. Awareness survey, safety measures and precautions to combat tomato fever-a prospective observational study. J Current Med Res Opinion. 2022;5(8):1353-65.

DOI and Others

DOI: 10.7860/JCDR/2023/61125.18069

Date of Submission: Nov 01, 2022
Date of Peer Review: Dec 20, 2022
Date of Acceptance: Feb 08, 2023
Date of Publishing: Jun 01, 2023

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 02, 2022
• Manual Googling: Dec 28, 2022
• iThenticate Software: Feb 04, 2023 (19%)

ETYMOLOGY: Author Origin

EMENDATIONS: 7

JCDR is now Monthly and more widely Indexed .
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