Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018




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On Sep 2018




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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Lucknow
On Sep 2018




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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
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Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

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In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
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Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Original article / research
Year : 2023 | Month : June | Volume : 17 | Issue : 6 | Page : ZC04 - ZC09 Full Version

Morphometric Analysis of Greater Palatine Foramen and the Adjacent Structures: Forensic Odontology Study using CBCT


Published: June 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/61961.18049
Winnifred Christy, S Annapoorani, T Jones Rajadeva Thambi, Mahalakshmi

1. Professor and Head, Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India. 2. Intern, Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India. 3. Reader, Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India. 4. Reader, Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India.

Correspondence Address :
S Annapoorani,
82B, South Masi Street, Madurai-625001, Tamil Nadu, India.
E-mail: annapooranipadma@gmail.com

Abstract

Introduction: Sexual dimorphism plays a pivotal role in many instances, including solving medicolegal problems, anthropological studies, sorting out victims of natural calamities and man-made calamities. Among various parameters available for sexual dimorphism, structures of the oral cavity play an important role. The use of Cone Beam Computed Tomography (CBCT) is convenient and provides accurate measurements with the help of digital software.

Aim: To determine the role of Greater Palatine Foramen (GPF), its Greater Palatine Canal (GPC) and relation with the adjacent structures like Nasopalatine Foramen (NPF) and Lesser Palatine Foramen (LPF) in elucidating the level of sexual dimorphism using CBCT images, while enhancing the information on anatomy of Greater Palatine Foramen (GPF).

Materials and Methods: This cross-sectional forensic odontology study was conducted in the Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India, and was performed using 50 males and 50 females CBCT images of patients between age 18 to 45. The CBCT data were collected from January 2021 till January 2022, and the obtained data were analysed from March 2022 till April 15, 2022. These were analysed using Planmeca imaging software. Measurements of GPF length, angulation with respect to Hard Palate (HP), relation between NPC and GPF, distance between GPC and Mid Maxillary Suture (MMS). Its relation to LPF and dimensions of GPF at opening of oral cavity were done. Finally, all measures were subjected to statistical analysis using IBM Statistical Package for the Social Sciences (SPSS), version 28.0. Independent t-test was used for analysis of difference between male and female measurements.

Results: The GPC length on right (male: 13.2570, female: 12.3628) and left (male: 12.8089, female: 12.2780), angulation between left GPC and hard palate (HP) (male: 61.1379, female: 57.4964), angle between GPF and NPC left (male: 28.6208, female: 26.5024), distance between GPC and MMS left (male: 15.1625, female: 14.5350) and Anteroposterior (AP) dimensions of GPF on right (male: 5.5402, female: 4.2314) and left-side (5.4934, female: 4.4576), Transverse dimension of GPF on right (male: 2.6752, female: 2.0528) and left (male: 2.6616, female: 2.1544) showed statistically significant difference between male and female CBCT images, while the measures were significantly higher in males.

Conclusion: The CBCT images provided reliable measurements of the areas of interest. The present study results highlight a statistically significant difference between male and female, where males showed higher measurements in most instances. A more precise morphological measurement of GPF in relation to adjacent structures such as NPC, MMS proves to have sexual dimorphism in humans.

Keywords

Cone beam computed tomography, Medicolegal cases, Nasopalatine foramen, Sexual dimorphism

One of the most amazing naturally occurring phenomena in various animals, including humans, is sexual dimorphism (1),(2). Men and women vary anatomically in many ways that go far beyond physical appearance or the presence of primary and secondary sexual characteristics. Despite having the same number of bones, males and females display a variety of differences that are not always obvious. Careful research is, therefore, required to identify the sexual dimorphism that exists in humans so that it can be effectively applied when necessary. According to reports, the skull and pelvis continue to be the most accurate sex indicators (3). Additionally, it has been demonstrated that there are differences in size, shape, and location between males and females in the foramen of the head and neck area, such as the foramen magnum, mental foramen, infraorbital foramen, and carotid canal. They are regarded as being structures with greater clinical relevance and significance (3). Anatomical structures like the HP are heat resistant and continue to be an ideal structure for sex determination, according to a study by Holland (4) that, found that even in conditions of extreme heat, the cranial bones experience minimal morphological changes. The differences in HP dimensions have been thoroughly researched. According to a recent study by Mustafa AG et al., the structures of the HP, such as its dimensions and the morphology of the NPF, vary between males and females (5). The promise of GPF’s sexual dimorphism traits, which have gone largely unnoticed over time, should also be given top priority. The quantity of information accessible for each person is directly correlated with the validity and legitimacy of the process of human identification or sexual dimorphism. In most cases, the full skeleton won’t be accessible, so the maximum amount of data cannot be retrieved. In such cases, meticulous assessment of all available bone will be an ideal condition for sex determination (6) and in such conditions, GPF plays a pivotal role. Thus, the analysis of GPF in relation with adjacent anatomic structures including NPF, MMS and LPF results in better sensitivity and reliability. Adding to this, the above mentioned structures are often stable and exhibit less deviation from normal (5).

The majority of research on the anatomical changes in the cranial base and HP has been done on dried bones (6),(7),(8),(9). Due to CBCT’s benefits of high-resolution pictures, quicker, more efficient imaging, and less radiation exposure, its usage of dried bones has been eclipsed. In literature, few articles have been put forth demonstrating the anatomical variances of GPF using CBCT (8),(9),(10),(11),(12). The hard palatal length and width is higher in males than females (8) and majority belonged to brachystaphyline type. The Nasopalatine Canal (NPC) proves to show higher measurements in male and the size is irrespective of the type of canal (9). These articles were mainly emphasising the anatomic aspects of GPF among different populations. This is the first kind of study emphasising the forensic property of GPF using CBCT. The present study is deviated from all the conventional measures by using CBCT as a tool to examine GPF for its sexual dimorphism.

With this background, the aim of the study is to determine the role of GPF, its GPC and relation with the adjacent structures like NPF and LPF in elucidating the level of sexual dimorphism using CBCT images while enhancing the information on anatomy of GPF.

Material and Methods

This cross-sectional forensic odontology study was conducted in the Department of Oral Medicine and Radiology, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India. The CBCT data were collected from January 2021 till January 2022, and the obtained data were analysed from March 2022 till April 15, 2022. The assessment of sexual dimorphism using GPF, inclusive of the adjacent structures was carried out using 100 CBCT images (50 males and 50 females) of complete maxilla. The CBCT images of the patients, who were advised to undergo imaging for dental treatment were collected from archives. The CBCT images were obtained using standard exposure (85 kVp, 5-7 mA for scanning time of 14 seconds) and patient positioning protocols with CBCT unit (Planmeca Promax 3D Classic CBCT Unit). The obtained images were then analysed using Planmeca Romexis 3D imaging software, which provides detailed dimensional measurements of all anatomic structures under consideration.

Sample size calculation: Sample size adequacy for the present study was calculated using G Power 3.1.9.7 with effect size of 0.32 (13) and actual Power of 0.95.

Inclusion Criteria:

• Patients above 18 years of age.
• Complete maxillary arch CBCT image.
• Images with no artifacts and no compromise in quality.

Exclusion Criteria:

• Partially or completely edentulous maxilla.
• Presence of any disease condition in jaw- cancer, vascular malformations, benign tumour etc.
• Patients currently undergoing orthodontic treatment.
• Patients with congenital abnormalities such as cleft palate.
• Patients having high arch palate.

Study Procedure

A morphometric analysis was performed. Initially, the GPF was located in Axial Plane (AxP), using this GPC was located in Sagittal Plane (SP). Further, two stabilised planes Plane 1 and 2 were established as reference to avoid bias between patients while undergoing further measurements.

Plane 1: S1- at the base of pterygopalatine fossa
Plane 2: S2- at the level of GPF (Table/Fig 1)

Following morphometric measurements were made by a single investigator, expressed in millimeters for males and females.

In sagittal plane (Table/Fig 2):

• Length (Le) of GPC from center of S1 to S2 in right (Le RGPC) and left (Le LGPC) sides (Table/Fig 2)a.
• Angulation of GPC with respect to line parallel to HP in right (A RGPC-HP) and left (A LGPC-HP) sides (Table/Fig 2)b.
• Distance between GPF and the nearest LPR in right (D RGPF-LPF) and left (D LGPF-LPF) sides (Table/Fig 2)c.
• AP diameters of GPF at S2 in right (AP-RGPF S2, TR-RGPF S2) and left (AP-LGPF, TR-LGPF) sides.
• The number of LPF present in right and left-sides (Number of LPR-right, number of LPR-left).
• The shape or course of GPC.

In Axial Plane (AxP) (Table/Fig 3),(Table/Fig 4):

• AP and TR diameters of GPF in right (AP-RGPF, TR-RGPF) and left (AP-LGPF, TR-LGPF) sides (Table/Fig 4)a,b.
• Distance (D) between upper end of GPF to lower center of NPF in right (D NPF-RGPF) and left (D NPF-LGPF) sides (Table/Fig 3)b.
• Angle (A) formed between upper end of GPF to lower center of NPF and MMS in right (A RGPF-NPF-MMS) and left-sides (A LGPF-NPF-MMS) (Table/Fig 3)a.
• Distance between upper end of GPF to MMS (D RGPF-MMS, D LGPF-MMS) (Table/Fig 3)c.

D NPF-GPF, A GPF-NPF-MMS were measured to analyse variations in relation between GPF, NPF, MMS in view of facilitating easy identification of GPF during surgical procedures and also, for the purpose of sexual dimorphism.

Statistical Analysis

The statistical analysis was carried out in IBM SPSS version 28.0. Descriptive statistics was carried out and reported as mean±Standard deviation. The association between males and females were assessed using independent student t-test. Paired sample test was done to find variations between right and left-sides in male and female, separately. Chi-square test was carried out to find age differences in males and females, separately. Following this multiple logistic regression analysis was carried out to frame the prediction model. From the regression analysis results, the values of constants and non standardised coefficients were fitted into formula along with the dependent variables.

Y=Constant+β1X1+β2X2+….+β*X*,

where, Y is the value to be found, in our case gender, β1, β2 are non standardised coefficients, X1, X2 are dependent variables which are the morphometric measurements. The accuracy of the generated equation was then assessed by carrying out similar morphometric assessment in 30 CBCT images with hidden identity. The values were then entered in the generated prediction equation and cross-checked.

Results

In the present study, a total of 100 CBCT images were examined, mean age of patients was 32.11±8 years. Out of 100 patients involved, 50 males and 50 females, 200 canal morphologies were evaluated.

Measurement in Axial Plane (AxP)

A statistically significant difference was found between AP, TN width of GPF in both right and left-sides. Males showed a greater diameter, when compared to females. Left-side showed a significant difference in angulation between GPF and NPF, a higher value was seen in males (mean=28.62°) than females (mean=26.50°) similarly distance between GPF and MMS was higher in males (mean=15.16 mm) than females (mean=14.53 mm) (Table/Fig 5). Distance between GPF and NPF in both right and left-sides, Angulation between GPF and NPF in right and distance from GPF to MMS in right-side showed statistically non significant results between males and females.

Measurements in Sagittal Plane

In sagittal plane, length of GPC in right and left-sides, angulation of GPC in left, distance between GPF and LPF in both sides showed statistically significant results (p<0.05). All the other values showed non significant results (Table/Fig 6). Additionally, the shape of GPC in sagittal plane was measured, this resulted that 83.23% of studied GPC showed straight path, while only a minor percentage of 16.77 showed curved path.

Prediction Formula

Two logistic regression analysis were carried out separately for axial and sagittal planes using only right-side values. Right-side values were chosen to formulate prediction equation as most of the measurements showed significant difference between male and female.

• Gender (in AxP): -.411+0.132 AP-RGPF+0.059 TN-RGPF+0.004 NPF- RGPF-0.001A NPF-RGPF+0.002 D RGPF-MMS.
• Gender (in sagittal plane): -2.105+0.94 Le RGPC+0.014 A RGPC-HP+0.165 D RGPF-RLPF+0.026 AP RGPF at S2

In both prediction equations, values less than one denotes female and more than one denotes male. The accuracy of the prediction equations was tested using 30 unidentified CBCT images and resulted to be 83% in AxP and 78.3% in sagittal plane.

Paired t-test within Male and Female

The paired t-test was carried out to compute differences between sides in males and females, separately. Almost all parameters resulted in a significant (p<0.05) difference between sides in females and males (Table/Fig 7). Of which comparatively strong statistical difference (p-value <0.01) was found in TN GPF, Distance between right GPF and NPF in females. While in males, a strong statistical difference was found in AP GPF, TN GPF, length of right GPF and angulation of right GPF. From the results, it can be interrupted that in females, most of the measured parameters showed greater mean values in left than in right-side (Table/Fig 7). On the other hand, males show greater mean values in right than in left-side.

Discussion

A number of techniques have been used in the past to determine a person’s sex, including visual inspection, tooth eruption order, chemical and physical analysis of calcified structures, Deoxyribonuleic acid (DNA) testing and examination of different skeletal structures (14). Because of the durability and secluded anatomic location in the base of the cranium, HP is one of the essential structures for sex identification. Likewise, the use of GPF as scientific evidence pertained to sexually dimorphic characteristics exhibited by human skeleton are used for administration of law and justice (15),(16). Numerous studies using both dry skull and three-dimensional imaging have been done in the literature to analyse the mastoid triangle, foramen magnum, HP, zygomatic arch, supraorbital ridges, orbital margins, and the position of the pterion, among other structures [17-20]. The few studies that are currently accessible have used dried bones (13),(21), and very few have used computed tomography (11),(12) for GPF evaluation. Various morphometric measurements were taken with a vernier calliper in traditional studies using dry skulls, and they were susceptible to examiner variability (7). The use of CBCT imaging now-a-days has become inevitable.

The accuracy and less time consumption of CBCT imaging systems has paved way for its application in studying the anatomic variations among skeletal structures. The accuracy of using CBCT in measuring the structures of interest is appreciable and with this key point the use of CBCT was considered as a foreseeable measurement tool in the present study. Stable HP landmarks were examined using CBCT in the present research, which yields more accurate results. The primary goals of the present study were to improve the data, that was already known and to add information about sexual dimorphism, that would aid in separating the human remains into males and females.

In the present study, there was substantial variability in measurements of GPF with its adjacent structures between males and females. When taking the dimensions of GPF in sagittal plane, it was found that the AP dimension of GPF was greater in males than females in both right and left-side. It can be interpreted that, females have a smaller GPF when compared to males. The mean AP and TN width of GPF obtained in our study is in accordance with study conducted by Nimigean V et al., (14). When right and left-side was compared in males and females separately, it resulted in a statistically significant result, with greater values in left-side in females and greater right-side values in males. Unlike the past studies (5),(21), which concluded to have no statistically significant difference in the distance between GPF and MMS, the present study found to have statistically significant difference between males and females in left-side, with males covering more distance in both right and left-sides. When analysing the relation between GPF and NPF, it was found that right-side showed significantly higher values than left-side in males and females. Like the above factors, males had higher angle and distance compared to females. This further adds on that, the position of GPF shows wide variation when observed with respect to NPF. From the AxP measurements, it can be stated that HP structure, especially GPF shows differences among males and females and even side differences in each gender.

The sagittal plane measurements include length of GPC, angulation of canal, AP dimension of GPF at S2, number of LPC and the distance between GPF and nearest LPF. From (Table/Fig 6), it is clear that, most of the above-mentioned parameters showed good statistical significance between male and female. Males had a greater length of canal in both right and left-sides. The canal angulation in females were more acute than males when measured with respect to HP and a line connecting S1 and S2 in sagittal plane, on comparing the distance between GPF and the nearest LPF, it can be concluded that, the LPF was more adjacent in female, while LPF was located far in males. Males had higher number of LPC, when compared to females, but there was no statistically significant difference. When looking to side differences in males and females- females had increased length and angulation in right while males in left-side. When looking into the shape of GPC, almost all were straight in the present study as the part of canal below the base of pterygopalatine fossa was only studied. The findings of the present study are in harmony with studies conducted in a group of Lebanese population and Saudi population (Table/Fig 8) (11),(12),(14),(21). Their findings also reveal presence of significantly higher measurements in sagittal plane, when GPF and its relation to midline is taken into account. The harmony between the results of current study and previous studies provides validity to the present study reports and design.

Based on the included parameters, the formulated gender prediction model both for axial and sagittal measurements were tested and resulted to have good sex determination accuracy of 83% and 78.3% in axial and sagittal planes, respectively. The present study confirms that GPF, GPC like any other cranial structures is subject to sexual dimorphism. In the present study, differences were reported with respect to dimensions of GPF, length and angulation of GPC and its relation with adjacent structures like NPF, LPF. Side-related discrepancies separately in males and females, were also reported.

Limitation(s)

The major limitation of the study was small sample size and restriction to limited group of population. The value of the present study can be improvised, by expanding it to a larger scale of population and comparing with various groups of people.

Conclusion

Although various parameters are available for forensic identification, thorough analysis of GPF, GPC can serve as an additional tool for sex determination. Various parameters pertained to GPF showed dimorphism. Additionally, two multiple logistic regression models were designed to predict sex, which resulted in a satisfactory accuracy of 83% and 78.3%. This, method proves to be a reliable one for identification and would be of immense help in instances of gross damage of individuals or if, the quantity of human remains found is low. The differences shown above can be taken into account during GPN anaesthesia, to obtain high success rate and reduce difficulty, while locating the canal.

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DOI and Others

DOI: 10.7860/JCDR/2023/61961.18049

Date of Submission: Dec 03, 2022
Date of Peer Review: Feb 15, 2023
Date of Acceptance: Mar 18, 2023
Date of Publishing: Jun 01, 2023

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 05, 2022
• Manual Googling: Feb 14, 2023
• iThenticate Software: Mar 07, 2023 (3%)

ETYMOLOGY: Author Origin

EMENDATIONS: 6

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