Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
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Aug 2018

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
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Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2023 | Month : June | Volume : 17 | Issue : 6 | Page : ZC25 - ZC28 Full Version

Treatment of Dentinal Hypersensitivity with Diode Laser of Two Different Wavelengths- A Randomised Clinical Trial

Published: June 1, 2023 | DOI:
Gautami S Penmetsa, Sravanthi Vundavalli, B Anusha, MAKV Raju, NVS Sruthima, Sathyavalli Veluri, N Hari Priya, Bharghavi Patnaik

1. Professor and Head, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 2. Postgraduate, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 3. Senior Lecturer, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 4. Professor, Department of Orthodontics, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 5. Professor, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 6. Postgraduate, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 7. Postgraduate, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. 8. Postgraduate, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Correspondence Address :
Sravanthi Vundavalli,
Postgraduate, Department of Periodontics and Implantology, Block 2, Vishnu Dental College, Vishnupur, Bhimavaram-534202, Andhra Pradesh, India.


Introduction: Dentinal Hypersensitivity (DH) is one of the most prevalent dental issues that is treated by both periodontists and endodontists. Hypersensitive dentin is a sensitive or painful response that is one of the most prevalent and poorly treated chronic dental disorders. Due to the difficulty in treating cervical DH, a great range of approaches and therapeutic procedures for pain relief in have developed. Treatments with desensitising drugs have been combined with laser treatment in recent decades. The most often utilised lasers in the treatment of DH are Diode Lasers (DL). DL act on DH provoking a melting effect with crystallisation of dentine inorganic component and the coagulation of fluids contained into the dentinal tubules.

Aim: To compare the effectiveness of DL of two different wavelengths in managing DH.

Materials and Methods: This split-mouth randomised clinical trial conducted in the Department of Periodontology at Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. The duration of the study was, from October 2021 to December 2021. A total of 12 patients with DH were selected and assigned to two groups. All the patients were subjected to desensitisation using DL of two different wavelengths 475 nm Bluelase system and 810 nm. Denlase system and parameters were evaluated 15 minutes after treatment, 7 days, 15 days and 30 days after treatment. Data were entered in Microsoft excel and analysed using Statitical Package for Social Sciences (SPSS) version 10.5 software.

Results: The mean age of the study participants was 45±3 years. There was a significant difference (p-value <0.001) in tooth sensitivity values measured at baseline, and at different time intervals in both groups. Among the two groups, Denlase group showed the greatest reduction in Visual Analogue Scale (VAS) scores from baseline to one month recall compared to Bluelase laser group. Highly significant difference was found when mean VAS scores were compared between baseline and all the other time points (p-value <0.001).

Conclusion: The present study concluded that, based on the results obtained, DL of 810 nm Denlase system was effective than DL of 475 nm Bluelase system in reducing the DH. Desensitisation treatment with laser irradiation has shown to be effective in the present study.


Denlase, Desensitisation, Laser therapy

The DH is characterised by sharp, short pain arising from exposed dentin in response to stimuli typically tactile, evaporative, thermal, chemical, osmotic, that cannot be attributed to any other pathology. It is one of the common problems encountered in dental practice (1). Although, sensitivity can occur on any part of the tooth, it is most commonly felt in the cervical region and on the tooth root surface. Frequency ranges between 3%-57%, and is much more frequent in patients suffering from periodontal disease (2). Denudation of dentin mainly occurs due to two reasons: i) removal of enamel for any reason; ii) denudation of root surface following the loss of cementum and recession of the supporting periodontal tissues (3). With the advancements in dentistry and oral hygiene promotion, greater proportion of the older population is retaining their teeth, and thus, the prevalence of denuded root surfaces following gingival recession and periodontal surgery is raising (4). DH occurs according to the hydrodynamic theory, where external stimuli cause the movement of fluid inside the dentinal tubules inwards or outwards, promoting mechanical deformation of nerve ending at the pulp dentine interface, which is transmitted as pain sensation (5).

The effectiveness of the various treatment options for DH is directly associated with the sealing of dentinal tubules to prevent dentinal fluid flow or blocking nerve activity. Difficulty in treating cervical DH gave rise to a large number of techniques and therapeutic procedures which are currently used for pain alleviation. In recent decades, treatments with desensitising agents have been supplemented using a laser (4). The development of laser technology over last few decades, as well as, its widespread use in dentistry, has provided a new therapeutic alternative for the treatment of DH. Most often used lasers in the treatment of DH are DLs (6). Treatment with laser irradiation has shown to be effective in recent research. Studies have addressed the safety of using a laser for treating DH, analysing the possibility of laser-induced pulp damage. One such study found that, if the temperature increase within the pulp remains below 5°C, then no pulp damage is evident. This thermal threshold is generally not exceeded when the energy and power settings of the laser remain within reported ranges (7). The mechanisms of laser therapy for DH remain unknown. Depending on the active medium, wavelength, power density of the laser, and the optical properties of the target tissue, the laser produces various tissue reactions by interacting with it. A laser must melt and resolidify the dentin surface to change it. Dentinal tubules are effectively closed. Laser therapy is thought to lessens sensitivity by coagulation and protein precipitation of plasma in the dentinal fluid, or by changes in nerve fibre activity, according to Pashley DH (8).

The majority of research using various types of lasers, different wavelengths, and varying durations of application suggest that, this treatment is successful, immediately after treatment and later on. DH has traditionally been treated with lasers of various wavelengths (810, 940, and 980 nm) (9). As a new horizon in the field of dentistry, a DL device emitting blue light was introduced.

This Bluelase system has several benefits, including high working effectiveness at low power levels and low depth of absorption of light at 475 nm, indicating minimal harm to the pulpal tissues (10). There is very little literature on comparing different wavelengths of the lasers. Thus, the primary aim of the study was to compare effectiveness of DL of two different wavelengths (475 nm with 810 nm) in managing DH.

Material and Methods

This split-mouth randomised clinical trial conducted in the Department of Periodontology at Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. The duration of the study was, from October 2021 to December 2021. The study was approved by the Institutional research committee and ethical clearance was obtained from the Institutional Ethics Committee (IECVDC/2021/PG01/PI/IVV/48) CTRI/
2021/08/035329. Written informed consent was obtained from patients who were willing to participate voluntarily. (Table/Fig 1) shows the Consolidated Standards of Reporting Trials (CONSORT) flow diagram of study participants.

Sample size calculation: Calculations to determine the sample size was performed using G-Power 3.1 software. The calculations were based on an effect size of 0.38 (4) and an α-value of 0.5 with a desired power of 80%. The estimated sample size was 10 patients. Considering 10% loss of follow-up, 12 patients were included in the study.

Inclusion criteria: A total of 12 systemically healthy patients, previously untreated for DH, aged between 18-60 years with a chief complaint of DH, contributing 68 teeth were enrolled for the study. Patients in good systemic health with clinically elicitable dentin hypersensitivity who were reliable in their response to test measurements and those, who were not treated earlier for DH were included in the study.

Exclusion criteria: Patients with any systemic diseases or conditions and those, who were on any analgesics/anti-inflammatory drugs at the time of the study. Patients who had used any desensitising paste or mouthwash during the last six months and patients with cracked teeth, large carious lesions or restored teeth and wasting diseases were excluded in the study.

Study Procedure

A total of 12 systemically healthy patients, previously untreated for DH, aged between 32-60 years with a chief complaint of DH, 12 patients contributing 68 teeth were enrolled for the study. A 2-4 teeth were treated in each side. The patients who satisfied all the inclusion and exclusion criteria were enrolled in the study. DH was assessed using evaporative stimuli. The evaporative stimulus was performed using an air syringe of the dental unit that was directed to the exposed tooth area for three seconds at a distance of 1 cm and a right angle to the buccal site of the assigned teeth. The patient then was asked to record their comfort by marking a point on a 10 cm VAS. A 0-10 numerical pain rating scales was given to the patient and they were asked to rate their pain. 0: no pain, 1-3: mild pain, 4-6: moderate pain, 7-10: severe pain.

In each patient, hypersensitivity teeth in two different quadrants were randomly assigned to one of the two treatment groups by the coin toss method.

Group 1: diode laser 810 nm-Denlase system
Group 2: diode laser 475 nm-Bluelase system

After the oral prophylaxis, baseline hypersensitivity scores were noted. The DL of wavelength 810 nm and 475 nm of frequency 15 Hz and power of 0.5 W in a continuous mode for one minute (4) was directed onto the hypersensitivity tooth surfaces and parameters were evaluated for 15 minutes, 1 week, 14 days, and 1 month after treatment (Table/Fig 2),(Table/Fig 3),(Table/Fig 4),(Table/Fig 5).

Statistical Analysis

Repeated measures of Analysis of Variance (ANOVA) and Bonferroni test was used for statistical analysis. Data were entered in Microsoft Excel and analysed using SPSS version 10.5. Bonferronni test was used for pair-wise comparison between the group/visit. The results were averaged (mean±standard deviation) for continuous data. p-value <0.05 was considered statistically significant.


The mean age of the participated subjects was 45±3 years. A total of 12 subjects were included in the present study. Patients who presented with cervical hypersensitivity when the air was delivered against the tooth surface were enrolled in the study. No adverse effects had been observed in any of the cases during the study. The mean VAS score for the Denlase group at baseline was 8.38±1.01 and after the treatment mean value reduced to 0.64±1.27 after 15 minutes, 0.29±1.03 at one week, 0.26±0.96 at 15 days and one month with a p-value <0.001 at all time intervals which was highly statistically significant (Table/Fig 6). Data for pair-wise comparison has been given in (Table/Fig 7). Highly significant difference was found, when mean VAS scores were compared between baseline and all the other time points (p<0.001).

The mean VAS score for the Blulase group at baseline was 7.73±2.67 and after the treatment mean value reduced to 2.23±1.67 after 15 minutes, 1.94±1.55 at one week and 14 days, 1.85±1.50 at one month with a p-value <0.001 at all time intervals which was highly statistically significant (Table/Fig 8). On pair-wise comparison significant difference was found when mean VAS scores were compared between baseline and all the other time points (Table/Fig 9). On intergroup analysis, there was significant reduction in mean VAS scores in Denlase group when compared to Bluelase group at all time periods except baseline (p<0.001). Hence, Denlase laser performed better in reduction of sensitivity when compared to Bluelase group (Table/Fig 10).


The main hypothesis evaluated in the present study was, whether applying an 810 nm DL and a 470 nm DL to a tooth with DH for 60 seconds would result in a significantly larger immediate reduction of DH. Denlase group was better when compared to Bluelase group in reducing the DH. The dentinal hypersensitivity is a quite common issue found in a dental practice that is characterised by a sharp, transitory unpleasant response to a stimulus such as eating, drinking, brushing one’s teeth, or breathing, thus, impacting the quality of life (11). Individual treatment needs for DH vary depending on the aetiology, as well as, the subjective perception of painful sensations and the degree of tolerance to this type of pain (12) because the aetiology of DH may be complex, evidence from past studies suggest that, many techniques have been used during treatment to achieve excellent results.

Traditional DH treatment involves using desensitising agents to obliterate the dentinal tubules that are exposed to the oral environment. Since, the use of tubule occlusive agents have several drawbacks, such as, the necessity for multiple administrations, a longer treatment time, and poor patient compliance, the demand for alternate treatment techniques has arisen. In the last decade, laser technology has given rise to a new therapeutic option for DH. The majority of experimental and clinical research on the effectiveness of Low-Level Laser Treatment (LLLT) on DH used DLs with wavelengths ranging from 635-910 nm (13). Low-power lasers have been used to treat DH using a variety of irradiation techniques. Their interaction with dental pulp creates a photo-bio modulating effect, increasing the metabolic activity of odontoblastic cells and, as a result, obliteration of the dentinal tubules and intensification of tertiary dentin formation. Furthermore, the low-power laser is thought to enhance cell circulation and activity, resulting in anti-inflammatory effects, analgesia, and tissue normalcy (14). Until now, DLs of various wavelengths, such as 660, 810, 940, and 980 nm, have been used in the treatment of DH [4,14]. Recently, a blue DL device was developed, a new laser that is now available in the field of medicine and dentistry. This Bluelase system has several benefits, including high working effectiveness at low power levels and a low depth of absorption of light at 475 nm, which indicates minimal harm to the pulpal tissues (8).

In the present study, there was a decrease in sensitivity ratings on the VAS scale in both groups from baseline to 15 minutes after treatment, with a significant difference. The results were similar to those achieved in a study by Dilsiz A et al., in which Nd: YAG and a 685 nm DL were utilised to treat DH and provide immediate relief. Their findings revealed a considerable reduction in DH, as well as, rapid and long term therapeutic effects on teeth with gingival recession (15). In a clinical study, conducted by García-Godoy F, 660 nm was used in the treatment of DH after non surgical periodontal therapy. He reported a statistically significant reduction in hypersensitivity immediately after therapy (after two minutes), two weeks, one month, and two months after treatment. The findings were similar to those of the current investigation (16). The results obtained were comparable to the results obtained in the study by Bilichodmath R et al., where they compared Stannous Fluoride (SnF2) and DL in the treatment of DH for providing instant relief (4). In clinical investigations by Tabatabaei MH et al., Garcia-Delaney C et al., and Hashim NT et al., found that, DL was successful in delivering instant alleviation of hypersensitivity. The findings of the current investigation were comparable to the above mentioned studies (3),(17),(18).


In the present study, the authors have used single energy level and single application of laser for desensitisation, which could be a limitation to the present study.


Desensitisation treatment with laser irradiation has shown to be effective in the present study, 810 nm DL has shown to be more effective in treating hypersensitivity when compared to 475 nm DL at different time intervals. Further long term research is required to evaluate the predictability and the effectiveness of lasers in the treatment of DH.


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DOI and Others

DOI: 10.7860/JCDR/2023/59983.18073

Date of Submission: Sep 01, 2022
Date of Peer Review: Nov 03, 2022
Date of Acceptance: Jan 12, 2023
Date of Publishing: Jun 01, 2023

• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes

• Plagiarism X-checker: Sep 20, 2022
• Manual Googling: Dec 27, 2022
• iThenticate Software: Jan 07, 2023 (21%)

ETYMOLOGY: Author Origin


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