
R-Spondins and Wnt Signalling Pathway: A Periodontal Perspective
Correspondence Address :
Dr. NK Savithri,
La Habitat, Flat S1, Block C, Dhanalakshmi Nagar, Moulivakkam, Chennai,
Tamil Nadu-600125, India.
E-mail: savithri.krishnan0@gmail.com
Periodontitis is a multifactorial chronic condition associated with the formation of a dysbiotic biofilm, leading to inflammation that can modulate cell signaling. R-spondins (Rspos) are cysteine-rich secreted glycoproteins which control a variety of functions which are essential for embryonic development and tissue homeostasis. Numerous studies have explained about their pivotal role in critical developmental regulators, the most important finding being Rspos synergise Wingless/Integration (Wnt) signaling. Novel receptors for Rspos, the Leucine-rich repeat containing G protein-coupled (LGR) receptors, proposed that Rspos potentiate canonical Wnt signaling via these receptors. Here, authors discussed about the Wnt signaling and outlined the biological role of Rspos in tissue development and homeostasis and explore the possibility that Rspos may be used as therapeutic targets. Wnt5a is important for promoting periodontal ligament remodeling and impairing regenerative responses modulated by the Wnt/β-catenin pathway, for alveolar bone formation.
Osteoprotegerin, Periodontal disease, Receptors, Wingless/Integration
DOI: 10.7860/JCDR/2023/61653.18108
Date of Submission: Nov 22, 2022
Date of Peer Review: Jan 07, 2023
Date of Acceptance: Feb 20, 2023
Date of Publishing: Jun 01, 2023
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 30, 2022
• Manual Googling: Feb 14, 2023
• iThenticate Software: Feb 18, 2023 (25%)
ETYMOLOGY: Author Origin
EMENDATIONS: 6
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com