Role of Maternal Anogenital Distance Measurement in Prediction of Perineal Tears during Vaginal Delivery: A Prospective Cohort Study
Correspondence Address :
Karishma Singh,
Plot No 31, Pocket 1, Sector 7, Ramprastha Greens Vaishali, Ghaziabad-201010, Uttar Pradesh, India.
E-mail: singhkarishma24@gmail.com
Introduction: Almost 85% of women suffer from perineal trauma during vaginal birth, which can have long-term consequences. Anogenital Distance (AGD) is a novel and useful parameter for predicting perineal tears during vaginal delivery.
Aim: To determine the accuracy and cut-off values of AGD in predicting ≥2nd degree perineal tears.
Materials and Methods: A prospective cohort study was conducted in the Department of Obstetrics and Gynaecology at GTB Hospital, New Delhi, India, from January 2021 to April 2022, including 80 patients in group 1 and 80 in group 2. Group 1 consisted of patients who experienced ≥2nd degree perineal tears during vaginal delivery, while group 2 included patients with an intact perineum or up to 1st degree tears. Anthropometric data such as Anus to Clitoris Distance (AGDac) and Anus to Fourchette Distance (AGDaf) (anus to fourchette distance), as well as labour parameters like foetal position, duration of the second stage, induction of labour and birth weight, were noted. Receiver Operating Curves (ROC) were plotted to obtain cut-off values for AGDac and AGDaf in predicting ≥2nd degree perineal tears. Unpaired t-tests and Chi-square tests were used to compare quantitative and qualitative parameters, respectively.
Results: The mean AGDac (75.99 vs. 77.05) and AGDaf (33.50 vs. 34.52) were lower in group 1 compared to group 2. AGDaf (75%) showed better sensitivity for predicting ≥2nd degree perineal tears and anal sphincter injury compared to AGDac (60%). The specificity of AGDaf (55%) was better for predicting ≥2nd degree perineal tears, while AGDac (51%) was more specific for sphincter injury. Foetal head position (p=0.016) and birth weight (p=0.002) were identified as the strongest risk factors for tears. Group 1 patients reported more bowel (25% vs. 10%) and prolapse symptoms (11.5% vs. 3.75%) compared to group 2 patients at six weeks postpartum.
Conclusion: Perineal length, as measured antenatally by AGD (both AGDac and AGDaf), is useful in predicting the occurrence of perineal tears during vaginal delivery. If found to be short, obstetricians can exercise greater caution during delivery, potentially reducing the incidence of anal sphincter injuries and their long-term consequences.
Anus to clitoris, Anus to fourchette, Anal sphincter, Episiotomy
Almost 85% of women experience some form of perineal trauma during vaginal birth, with the incidence of anal sphincter injury ranging from 0.5% to 7% (1). Perineal tears can lead to significant postpartum complications, both short-term and long-term, including psychological effects. Short-term complications may include pain, discomfort, increased blood loss, haematoma and infections. Long-term complications can involve chronic infections, urinary, faecal and flatus incontinence, sexual dysfunction and pelvic organ prolapse (2). Risk factors for perineal tears include Asian ethnicity, nulliparity, occiput-posterior position, shoulder dystocia, prolonged second stage of labour, instrumental delivery and higher birth weight (3). A short perineal length of less than 35 mm has been associated with an increased risk of perineal tears (4).
Perineal tears are classified as follows (Table/Fig 1) (5): The AGD is an emerging anthropometric parameter and serves as a marker of genital development in humans, typically observed between 8 to 14 weeks of gestation (6). It reflects the hormonal environment surrounding the foetus during prenatal life. AGD exhibits sexual dimorphism, being 2 to 3 times longer in males than in females due to higher androgen levels (7). Studies have indicated an association between AGD and hormone-dependent conditions in females, such as endometriosis, Polycystic Ovary Syndrome (PCOS) and pelvic organ prolapse (8),(9). A short perineum has been correlated with an increased risk of perineal trauma, episiotomy and long-term pelvic organ prolapse (10),(11),(12). The current study aimed to assess the accuracy of AGD in predicting perineal tears during vaginal delivery. The secondary objectives are to determine the risk factors for perineal tears and to evaluate the Pelvic Floor Distress Inventory (PFDI) and pelvic floor muscle strength at six weeks postpartum.
A prospective cohort study was conducted in the Department of Obstetrics and Gynaecology at GTB Hospital, New Delhi, India, from January 2021 to April 2022. Ethical clearance was obtained from the Institutional Ethical Committee for human research (IECHR/2020/PG/47/42) and informed consent was obtained from the subjects.
After an extensive search, the authors found one study that was indirectly related, which provided a guiding number for the sample size (11).
Inclusion and Exclusion criteria: Primigravida patients with singleton pregnancies at ≥37 weeks in early labour were included in the study, while those with a history of pelvic floor trauma/surgery, instrumental delivery and malpresentation were excluded. Group 1 patients were defined as females sustaining ≥2nd degree perineal tears (including episiotomy, n=80), while group 2 patients were females with an intact perineum or sustaining up to 1st-degree perineal tears post-vaginal delivery (n=80).
Study Procedure
Anthropometric data such as AGDac (anus to clitoris) and AGDaf (anus to fourchette), along with labour parameters like foetal position, duration of the second stage, induction of labour and birth weight, were noted. AGD measurements were taken using digital vernier callipers by the same observer between contractions, with patients in the lithotomy position and thighs at an angle of 45 degrees to the examination table (Table/Fig 2). Each measurement was taken three times and the average for each AGD was calculated. The recruitment strategy has been summarised in the flowchart (Table/Fig 3).
Follow-up of the subjects was conducted at 6 weeks postpartum in the postnatal clinic, where the PFDI and pelvic floor muscle strength testing were performed to assess pelvic floor function. Of the 20 questions in the PFDI-20 form, each question had "yes" 7or "no" as potential answers. A "no" response corresponded to a score of "0." If the patient answered "yes," the response was based on an ordinal range from "1" to "4" in terms of bother and severity of symptoms (13).
For pelvic floor muscle strength testing, the examination was carried out after the patient emptied their bladder in a dorsal lithotomy position with knees semi-flexed. Patients were requested to contract the muscles of the pelvic floor and their responses were graded from 0 to 5 according to a validated Oxford scale (14).
Statistical Analysis
Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) version 22.0. The receiver operating characteristic curve was plotted to calculate the optimum cut-off values for AGD (AGDac and AGDaf). All continuous and categorical parameters were compared using an unpaired t-test and Chi-square test, respectively. Logistic regression analysis was conducted to identify the risk factors for the likelihood of perineal tears. A p-value of less than 0.05 was considered significant.
Demographic characteristics such as age, socioeconomic status, religion, education and Basic Metabolic Index (BMI) (kg/m²) were comparable in group 1 and group 2 (Table/Fig 4). The mean AGDac was shorter in group 1 compared to group 2, which was statistically significant (p-value of 0.029). Group 1 had a significantly shorter AGDaf compared to group 2 (p<0.001) (Table/Fig 5). Second-degree perineal tears, including episiotomies, were the most common perineal outcomes, accounting for 86.25%, followed by Obstetric Anal Sphincter Injuries (OASIS) at 8.75% and cervical or paraurethral tears at 3.75% (Table/Fig 6).
The left occiput anterior foetal head position and baby birth weight were significantly associated with the occurrence of second-degree or higher perineal tears (p=0.016 and p=0.002) (Table/Fig 7). Cut-off values obtained from the receiver operating curve (Table/Fig 8) for AGDac and AGDaf were 77.05 mm and 33.75 mm for predicting the occurrence of second-degree or higher perineal tears. However, AGDaf had better sensitivity (75%) and specificity (55%) for predicting these tears compared to AGDac (Table/Fig 9). The cut-off values obtained from the receiver operating curve (Table/Fig 10) for AGDac and AGDaf were 77.15 mm and 33.25 mm for predicting OASIS. AGDac exhibited better specificity (51%), while AGDaf demonstrated better sensitivity (71.4%) for predicting OASIS (Table/Fig 11).
At six weeks, patients in group 1 reported more bowel symptoms and symptoms pertaining to prolapse compared to group 2, while urinary symptoms were comparable in both groups, with no statistically significant difference found using the PFDI-20 (Table/Fig 12). Pelvic floor muscle strength, assessed by Oxford grading, was found to be comparable in both groups.
The mean AGDac was lower in group 1 and higher in group 2 (75.99±3.43 mm vs. 77.05±2.62 mm, p=0.029). The mean AGDaf was also lower in group 1 and higher in group 2 (33.50±1.65 mm vs. 34.52±1.25 mm, p<0.001). Moya-Jiménez LC et al., conducted an observational prospective cohort study to compare perineal measurements {gh+pb, as per the Pelvic Organ Prolapse Quantification system (POP-Q)} and AGD to determine which perineal measurement can predict the likelihood of episiotomy. The gh+pb measurement was 77 mm in the episiotomy group and 81.9 mm in the no-episiotomy group, while its counterpart AGDac was 93.1±9.4 mm in the episiotomy group and 97.8±10.2 mm in the no-episiotomy group (11).
In the study conducted by Moya-Jiménez LC et al., the AGDaf was 35.9±6.9 mm and 34.9±7.4 mm in the episiotomy and no-episiotomy groups, respectively. They found that shorter lengths of gh+pb and AGDac were risk factors for episiotomy, which were comparable to the current study’s results.
Additionally, AGDac was found to be a more specific predictor of OASIS, while AGDaf was identified as a better predictor of ≥2nd-degree perineal tears and episiotomy (11). These results were consistent with the current study.
A study conducted by Lane TL et al., assessed the relationship between perineal body length and perineal lacerations (4). The mean perineal body length was 37±0.5 mm and the study concluded that a perineal body length of ≤35 mm was predictive of 3rd or 4th-degree lacerations. Geller EJ et al., conducted a study to determine whether a shortened perineal body is a risk factor for ultrasound-detected anal sphincter tears at first delivery and concluded that a perineal body length of <3 cm was associated with a significantly higher rate of tears (15).
The mean birth weight in group 1 was 2.7 kg and 2.5 kg in group 2 (p=0.002), which was statistically significant, suggesting it is significantly associated with the occurrence of second-degree or higher perineal tears. The study conducted by Marschalek ML et al., also found that birth weight was significantly associated with a high likelihood of perineal tears, similar to the results of the present study (3). AGD is an emerging and lesser-explored area in obstetrics and Gynaecology. More studies should be conducted to fully understand its implications. Further studies are needed to validate these findings on a larger scale.
Limitation(s)
Only primiparous women were included, so the results cannot be generalised to multiparous women. Additionally, since this was a single-centre study, the findings cannot be generalised to the entire population.
The shorter Anus to Fourchette Distance (AGDaf) has been found to have good sensitivity for predicting second-degree or higher perineal tears. In predicting Obstetric Anal Sphincter injury specifically, AGDaf demonstrated better sensitivity than the Anus to Clitoris Distance (AGDac); however, its specificity was lower than that of AGDac. Measuring AGD with vernier callipers in obstetric patients is simple and can be performed easily. If AGD is found to be short, along with the presence of risk factors for perineal tears, the obstetrician conducting the delivery can take more precautions. This can help reduce the occurrence of obstetric anal sphincter injuries and their long-term consequences.
Declaration: The present article is published as Abstract 181- Role of Maternal Anogenital Distance Measurement in Prediction of Perineal Tears during Vaginal Delivery, Continence, Volume 7, Supplement 1, 2023, 100899, ISSN 2772-9737. htt://doi. org/10.1016/j.cont.2023.100899
Author contributions: KS- Data collection, data analysis, manuscript preparation; SJ- Protocol development, data collection, manuscript preparation; RA- Data collection, data analysis; BPData collection, data analysis.
The first author is deeply grateful to his Supervisor Dr. Sandhya Jain, Professor, Department of Obstetrics and Gynaecology, UCMS and GTB hospital, under whose able and expert guidance; she has been able to complete this dissertation and feels overwhelmed to express sincerest regards to her parents. Their constant love, sacrifices and prayers have been instrumental in her achievements.
DOI: 10.7860/JCDR/2024/73912.20293
Date of Submission: Jul 07, 2024
Date of Peer Review: Aug 08, 2024
Date of Acceptance: Oct 08, 2024
Date of Publishing: Nov 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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