
Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report
Correspondence Address :
Vineetha Naga Lakshmi Giduturi,
B-49, Old Girls Hostel, Dr. D. Y. Patil Medical College and Hospital, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, India.
E-mail: vineetha16giduturi@gmail.com
Iron Deficiency Anaemia (IDA) is a prevalent nutritional deficiency and a common haematological disorder characterised by low iron levels, which lead to reduced haemoglobin production, fatigue, pallor and diminished oxygen delivery. IDA increases the risk of venous thromboembolism by causing thrombocytosis, venous stasis and hypercoagulability. Although iron deficiency is a rare risk factor, recognising it as a significant risk factor can help prevent pulmonary thromboembolism if detected early and treated. The most common inherited thrombophilias—such as Factor V Leiden mutation, prothrombin G20210A mutation and deficiencies in protein C, protein S and antithrombin III—are a group of genetic conditions that predispose individuals to thrombotic events by influencing various factors involved in the coagulation cascade. Deep Vein Thrombosis (DVT) is a common condition that is part of venous thromboembolism disorders and represents the third most common cause of death from cardiovascular disease, following heart attacks and strokes. Authors hereby, report a rare and complicated case involving a 44-year-old male patient who experienced Pulmonary Embolism (PE), DVT, IDA and underlying abnormalities in two key anticoagulant proteins: Protein C and Protein S. Anticoagulation with low molecular weight heparin was initiated to treat the PE and DVT. Based on the patient’s thrombophilia profile, a newer oral anticoagulant, rivaroxaban, was prescribed as a long-term anticoagulant.
Iron deficiency anaemia, Protein C deficiency, Protein S deficiency, Rivaroxaban, Thrombophilia profile
DOI: 10.7860/JCDR/2025/74900.20563
Date of Submission: Aug 12, 2024
Date of Peer Review: Sep 05, 2024
Date of Acceptance: Oct 05, 2024
Date of Publishing: Feb 01, 2025
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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ETYMOLOGY: Author Origin
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