Cardioprotective Effect Of Momordica Cymbalaria Fenzl In Rats With Isoproterenol-Induced Myocardial Injury
Raju Koneri PhD, Professor of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, Banashankari, BANGALORE. E mail email@example.com
Momordica cymbalaria (M. cymbalaria) holds medicinal value and is used traditionally for treatment of various disorders. In the present study, we tested cardioprotective potential of M. cymbalaria against isoproterenol (ISO)-induced cardiac injury. Pretreatment with ethanolic extract of M. cymbalaria at 250 and 500 mg/kg prevented the elevation of serum marker enzymes, lactate dehydrogenase (LDH), creatinine kinase-MB Fraction (CK-MB), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and alterations in the oxidative stress markers like lipid peroxidase (LPO), glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) caused by ISO (60 mg/kg s.c, 2days)- induced myocardial infarction in rats. The protective effect was confirmed by histological findings and was more prominent at 500 mg/kg. Hence, we conclude that pretreatment with ethanolic extract of M. cymbalaria protects against isoproterenol- induced myocardial injury.