Microalbuminuria in Non-diabetic,
Non-hypertensive Myocardial Infarction in
South Indian Patients with Relation to
Lipid Profile and Cardiac Markers
Asistant Professor of Biochemistry
Ras Al Khaimah Medical and Health Sciences University, Ras Al
Introduction and Objective: The present study was carried out to compare the levels of urinary microalbumin, the lipid profile, the cardiac enzymes and troponin T in non-diabetic, non-hypertensive myocardial infarction patients and in healthy controls and to know the possible relationship between microalbuminuria and the lipid profile markers and the cardiac enzymes in myocardial infarction in patients from the southern part of India.
Materials and Methods: This study was carried out in 35 nondiabetic, non-hypertensive myocardial infarction patients and in 35 healthy, age matched controls. Urinary albumin, urinary creatinine, creatinine kinase-MB fraction (CK-MB), AST, LDH, troponin I and the lipid profile parameters were estimated by using an automated analyzer. The total cholesterol/HDL cholesterol ratio and the LDL cholesterol/HDL cholesterol ratio were also calculated by using the total cholesterol and the LDL and HDL values.
Results: There was a significant increase in the levels of total cholesterol, LDL cholesterol, total cholesterol/HDL cholesterol ratio, LDL cholesterol/HDL cholesterol ratio, microalbumin, cardiac enzymes and troponin I (p<0.001) in patients with myocardial infarction as compared to those in the healthy controls. On applying Pearsonâ€™s correlation, the microalbumin levels were found to correlate positively with the LDL cholesterol levels (p = 0.010, r = 0.952) and Troponin I (p=0.025, r = 0.885) and this was found to be statistically significant.
Conclusion: Microalbuminuria can be used as a predictor for the early detection of cardiovascular and renal changes along with the lipid profile markers in the general population to prevent the mortality and morbidity which are associated with acute myocardial infarction