Year :
2024
| Month :
July
| Volume :
18
| Issue :
7
| Page :
ED13 - ED16
Full Version
A Case of Paraganglioma as an Unusual Tenant of Gallbladder
Published: July 1, 2024 | DOI: https://doi.org/10.7860/JCDR/2024/68984.19600
Snehlata Hingway, Suhit Naseri, Pravin Gadkari
1. Professor, Department of Pathology, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
2. Resident, Department of Pathology, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
3. Professor, Department of Pathology, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
Correspondence Address :
Dr. Suhit Naseri,
Resident, Department of Pathology, Datta Meghe Institute of Higher Education and Research, Wardha-442107, Maharashtra, India.
E-mail: drsuhitnaseri@gmail.com
Abstract
Gallbladder paraganglioma is an exceptionally uncommon tumour. Paragangliomas are a subset of Neuroendocrine Neoplasms (NENs) called neurogenic NENs that arise from neural crest cells of the neuroectoderm. They present diagnostic challenges due to their uncommon occurrence and non specific clinical manifestations. The paraganglion system consists of two cell types, called chief and sustentacular cells. The most common location of a paraganglioma is the adrenal medulla, defined as pheochromocytoma. Pheochromocytomas, found in the adrenal medulla, are known for their high Catecholamine (CA) production, leading to significant clinical manifestations like hypertension and metabolic disturbances. A 36-year-old female, otherwise asymptomatic, underwent cholecystectomy due to persistent abdominal discomfort in the right hypochondrium for two months. Preoperative imaging demonstrated a gallstone. Laparoscopic cholecystectomy was performed. The pathological analysis following surgery documented the presence of gallbladder paraganglioma and chronic cholecystitis. Immunohistochemically, chief cells displayed widespread positivity for chromogranin, synaptophysin, and sustentacular cells displayed S100 positivity. There are no definitive guidelines for the management of gallbladder paragangliomas due to their rarity. Reporting instances of paraganglioma in the gallbladder is critical to raising clinical awareness, enhancing diagnostic criteria, optimising treatment protocols, and unravelling the underlying molecular mechanisms. All of these efforts are critical for improving patient care and outcomes in treating this uncommon and enigmatic tumour entity.
Keywords
Cholecystectomy, Histopathology, Neuroendocrine tumour, Paraganglia
DOI: 10.7860/JCDR/2024/68984.19600
Date of Submission: Dec 08, 2023
Date of Peer Review: Feb 15, 2024
Date of Acceptance: Apr 02, 2024
Date of Publishing: Jul 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 09, 2023
• Manual Googling: Feb 20, 2024
• iThenticate Software: Apr 01, 2024 (13%)
ETYMOLOGY: Author Origin
EMENDATIONS: 6
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